The best PC related prank to play in school is to swap all the mice and keyboards of the PCs if they are in rows next to each other. I.e. Plug the M&K for one PC, into the one next to it, but don’t move them. Nobody will notice as all the connections are around the back.
Anyway, my sister hasn’t found out yet, she doesn’t use the laptop that often, so it might be a couple of days before something happens.